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目的观察β-七叶皂苷钠治疗特发性面神经麻痹的临床疗效。方法选择符合条件的特发性面神经麻痹患者20例,随机分为治疗组和对照组各10例。对照组给予糖皮质激素,治疗组给予七叶皂苷钠20mg,1次/d,两组均给予多种维生素、神经营养剂及对症治疗,共14d。采用Sunnybrook(多伦多)面神经功能评分标准,于治疗前和治疗后第14天对两组患者进行神经功能缺损评分。结果治疗14d后,治疗组分值由治疗前的(17.00±10.89)分上升到治疗后的(75.10±12.31)分;对照组分值由治疗前的(18.20±9.83)分改变为治疗后的(76.60±12.79)分;两组治疗后比较,治疗方法的主效应差异无统计学意义(P>0.05),治疗时间效应有统计学意义(P<0.05)。治疗组无明显不良反应。结论β-七叶皂苷钠治疗特发性面神经麻痹具有激素治疗相同疗效。
Objective To observe the clinical efficacy of β-aescinate in the treatment of idiopathic facial paralysis. Methods Twenty patients with idiopathic facial paralysis were selected and randomly divided into treatment group and control group with 10 cases in each group. The control group was given glucocorticoid, the treatment group was given sodium aescinate 20mg, 1 times / d, both groups were given a variety of vitamins, neurotrophic agents and symptomatic treatment, a total of 14d. The Sunnybrook (Toronto) facial nerve function score was used to score neurological deficits in both groups prior to and 14 days after treatment. Results After treatment for 14 days, the value of treatment group increased from (17.00 ± 10.89) before treatment to (75.10 ± 12.31) after treatment, while that of control group changed from 18.20 ± 9.83 before treatment to (76.60 ± 12.79) points. There was no significant difference in the main effect between the two groups after treatment (P> 0.05). The effect of treatment time was statistically significant (P <0.05). Treatment group no obvious adverse reactions. Conclusion β-aescinate sodium treatment of idiopathic facial paralysis with hormone therapy with the same effect.