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目的探讨卵巢囊性颗粒细胞瘤的临床病理学特征、诊断及鉴别诊断。方法复习1例卵巢囊性颗粒细胞瘤的临床资料、大体及镜下组织病理学表现,行免疫组化染色,并复习相关文献。结果患者女性,30岁。右侧单房性卵巢囊肿,18.5 cm×16.5 cm×2 cm大小,囊壁厚薄不均;镜下囊内壁由多层颗粒细胞构成,部分囊壁可见散布实性成片的颗粒细胞;瘤细胞胞质稀少,核圆形、卵圆形,部分细胞有核沟。免疫组化:颗粒细胞α-inhibin、CD99和vimentin呈(+)。结论卵巢囊性颗粒细胞瘤较少见,正确诊断依靠组织形态学,特征为发现单纯一致的颗粒细胞、可见核沟及找到Call-exner小体或微滤泡结构;免疫组化染色有助于明确诊断。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of ovarian cystic granulosa cell tumor. Methods The clinical data of 1 case of ovarian cystic granulosa cell tumor were retrospectively reviewed. The gross and histopathological features of the ovarian cystic granulosa cell tumor were observed. The immunohistochemical staining and immunohistochemical staining were reviewed. Results Female patient, 30 years old. Right ovarian cysts, 18.5 cm × 16.5 cm × 2 cm size, uneven wall thickness; microscopic capsule wall composed of multi-layer granular cells, part of the wall can be seen scattered solid into pieces of granular cells; tumor cells Cytoplasmic scarce, nuclear round, oval, some cells have nuclear ditch. Immunohistochemistry: granulosa cells α-inhibin, CD99 and vimentin (+). Conclusion Ovarian cystic granulosa cell tumor is rare, the correct diagnosis depends on histomorphology, characterized by the discovery of purely uniform granulosa cells, showing the nucleus ditch and find Call-exner body or micro-follicular structure; immunohistochemical staining contribute to Clear diagnosis.