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一种可以恒定释放抗菌素-妥布霉素(TOB)的人造皮肤克服了以往人造皮易使患处感染的缺点。它由两层组成,上层为储药层,下层为胶朊海绵。储药层的主体是含有TOB的聚乳酸(PLA)微球(M-TOB)与胶朊的复合物。M-TOB的制法:将TOB与PLA的混合溶液在搅拌下滴入含乳化剂的棉籽油中,制成油包油型乳液,在40～45℃下脱除溶剂,将硬化的微球过滤、洗涤便可得直经为50～100μm的M-TOB。将M-TOB与0.3%的胶朊溶液混匀注入模具中,快速冷冻,于-20℃过夜,再冷冻干燥48小时,便得M-TOB与胶朊的复合物,表面贴以25μm的硅橡胶膜便制得储药层。作者对比地研究了M-TOB与储药层的T0B释放行为,并考查了储药层对微
An artificial skin that can consistently release the antibiotic tobramycin (TOB) overcomes the shortcomings of past artificial skins that are susceptible to infection in the affected area. It consists of two layers, the upper layer is the reservoir, the lower layer is a collagen sponge. The main body of the reservoir is a complex of polylactic acid (PLA) microspheres containing TOB (M-TOB) and glucoprotein. Preparation of M-TOB: A mixed solution of TOB and PLA is added dropwise to the emulsifier-containing cottonseed oil under stirring to prepare an oil-in-water emulsion, and the solvent is removed at 40 to 45 ° C. The hardened microspheres Filtration, washing can be straight through 50 ~ 100μm M-TOB. The M-TOB and 0.3% of the solution of glucoamylase mixed into the mold, rapid freezing, at -20 ℃ overnight and then freeze-dried for 48 hours to give M-TOB and glucoprotein complex surface affixed with 25μm silicon Rubber film will be made of storage layer. The authors compared the T0B release behavior between M-TOB and the storage layer and examined the effect of the storage layer on the micro