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目的评价含锌生物材料对于骨质疏松骨修复的作用。方法通过摘除成年雌性大鼠双侧卵巢(去势)的方法建立下颌骨骨质疏松动物模型,12周后检测模型成功后,建立下颌骨极限缺损模型,随后将动物随机分为3组。实验组植入含锌磷酸三钙陶瓷(Zn-TCP/HA),对照组植入双相磷酸钙陶瓷(β-TCP),空白对照组不植入材料。在植入材料12周后处死动物,进行组织学观察和生物力学检测。结果通过骨密度仪测试证实去势大鼠的下颌骨有骨质疏松发生;材料植入骨缺损部位12周后,通过影像学检查、生物力学检测以及组织学观察发现,实验组骨修复效果明显优于对照组和空白对照组。结论锌离子能够加速和改善骨质疏松骨缺损的修复。
Objective To evaluate the effect of zinc-containing biomaterials on bone repair of osteoporosis. Methods The animal model of mandibular osteoporosis was established by removing bilateral ovaries (ovariectomized) from adult female rats. After 12 weeks, the model of mandibular limit defect was established, and then the animals were randomly divided into three groups. The experimental group was implanted with zinc-containing tricalcium phosphate (Zn-TCP / HA), the control group was implanted with biphasic calcium phosphate ceramic (β-TCP), and the blank control group was not implanted with material. Animals were sacrificed 12 weeks after implantation of the material for histological observation and biomechanical testing. Results Osteoporosis was found in the mandible of ovariectomized rats by bone densitometry. After the material was implanted into the bone defect site for 12 weeks, the effect of bone repair in experimental group was obvious by imaging examination, biomechanical test and histological observation Better than the control group and blank control group. Conclusion Zinc ions can accelerate and improve the repair of osteoporotic bone defects.