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药物辨别实验方法是一种研究药物辨别性质的行为药理学方法。目前已广泛应用于中枢作用药物的精神依赖性评价中。本实验通过３种阿片类镇痛药－－－吗啡、盐酸二氢埃托啡（ＤＨＥ）和羟甲芬太尼（ＯＭＦ）在大鼠身上的辨别行为效应，对它们的精神依赖性潜力进行比较。结果表明：在相同的情形下，３药进行替代试验，吗啡的半数辨别效应剂量（ＤＤ５０）为１．２４ｍｇ·ｋｇ－１．ＤＨＥ和ＯＭＦ的ＤＤ５０分别为０．１６、０．９１μ·ｋｇ－１，两药在大鼠辨别实验中的效价分别约为吗啡的７７５０和１３６０倍。这提示ＤＨＥ在临床应用中可能有很强的请神依赖性潜力，应引起广大医务工作者的注意。
The experimental method of drug discrimination is a behavioral and pharmacological method to study the distinguishing characteristics of drugs. Has been widely used in the central role of drug dependence in the evaluation. In this experiment, the discriminatory behavioral effects of three opioid analgesics, morphine, dihydroetorphine hydrochloride (DHE) and oxymethaenamine (OMF), in rats were evaluated for their psychic dependence potential Compare The results showed that in the same situation, the substitution test of 3 drugs showed that the half dose of morphine (DD50) was 1.24 mg · kg -1. The DD50 of DHE and OMF were 0.16 and 0.91 μ kg-1, respectively. The titer of the two drugs in rat discrimination experiments were about 7750 and 1360 times that of morphine respectively. This suggests that DHE in clinical applications may have a strong demand for God-dependent potential, should arouse the attention of the majority of medical workers.