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目的探讨血液透析联合血液灌流治疗尿毒症神经系统损害的临床疗效。方法选取2010年12月至2012年12月三门峡市中心医院收治的尿毒症神经系统损害患者60例,随机分为观察组和对照组各30例,对照组采用血液透析治疗,观察组采用血液灌流联合血液透析治疗,观察比较两组临床症状、体征及血β2-MG浓度变化。结果观察组显效6例,有效7例,无效1例,总有效率为92.86%,对照组均无改善,观察组临床症状体征改善显著优于对照组(χ2=24.266,P<0.01)观察组血β2-MG浓度改善均优于对照组,两组比较差异具有统计学意义(P<0.05)。结论血液灌流联合血液透析治疗尿毒症神经系统损害的疗效显著,能有效改善患者临床症状和血β2-MG浓度,推荐临床推广应用。
Objective To investigate the clinical effect of hemodialysis combined with hemoperfusion on uremic nervous system damage. Methods Sixty patients with uremic nervous system damage admitted from Sanmenxia Central Hospital from December 2010 to December 2012 were randomly divided into observation group (30 cases) and control group (30 cases). The control group was treated by hemodialysis. The observation group was treated with hemoperfusion Combined with hemodialysis treatment, observed and compared the clinical symptoms and signs and blood β2-MG concentration changes. Results The observation group was significantly improved in 6 cases, effective in 7 cases and ineffective in 1 case, with a total effective rate of 92.86%. The improvement in clinical symptoms and signs in the observation group was significantly better than that in the control group (χ2 = 24.266, P <0.01) Blood β2-MG concentration were better than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Hemoperfusion combined hemodialysis treatment of uremic neurological damage significant effect, can effectively improve the clinical symptoms and serum β2-MG concentration, recommended for clinical application.