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目的研究 Th1/Th2型细胞因子产生在复发性生殖器疱疹（ RGH）发病机理中的作用及其相互关系。方法采用双色荧光抗体染色技术经流式细胞仪检测了 20例 RGH患者外周血 CD3＋ T细胞内 5种细胞因子染色阳性细胞百分率。结果 RGH患者 CD3＋总 T细胞百分率比正常人对照明显降低（ P< 0.05）； IL-2、 IFN－γ阳性细胞百分率均显著降低（分别为 P< 0.02及 P< 0.001）； IL-10、 IL-12阳性细胞则明显升高（均为 P< 0.01）； TNF－α阳性细胞则无明显改变（ P >0.05）。结论 RGH患者存在着因 Th1与 Th2细胞间的交互异常调节所致的有关细胞因子产生失衡，表现为 Th2型细胞因子（ IL-10）产生过多，而 Th1型细胞因子（ IL-2、 IFN－γ）产生过少，由此所引起的一系列细胞免疫反应抑制效应在 RGH发病机理中起着重要作用。
Objective To investigate the role of Th1 / Th2 cytokines in the pathogenesis of recurrent genital herpes (RGH) and their relationship. Methods The percentage of 5 cytokines positive cells in peripheral blood CD3 + T cells of 20 patients with RGH were detected by dual-color fluorescent antibody staining. Results The percentages of CD3 + T cells in RGH patients were significantly lower than those in normal controls (P <0.05), while the percentages of IL-2 and IFN-γ positive cells were significantly decreased (P <0.02 and P <0.001, respectively) -12 positive cells were significantly increased (both P <0.01); TNF-α positive cells had no significant change (P> 0.05). Conclusions RGH patients have unbalanced cytokine production due to abnormal interaction between Th1 and Th2 cells, showing excessive production of Th2 cytokines (IL-10), while Th1 cytokines (IL-2, IFN -γ) production is too small, resulting in a series of cellular immune response inhibitory effect in the pathogenesis of RGH plays an important role.