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为探讨甲基苯丙胺对其依赖人群血管内皮功能的影响,入选50例甲基苯丙胺依赖人群(Ⅰ组)和50例健康人群(Ⅱ组),2组人群均采用高分辨血管超声检测肱动脉血流介导的血管扩张功能(FMD),以及血中一氧化氮(NO)、内皮素-1(ET-1)水平。甲基苯丙胺依赖人群组(Ⅰ组)肱动脉FMD、血一氧化氮(NO)水平较健康对照组(Ⅱ组)显著降低(p<0.05);血内皮素-1(ET-1)水平较健康对照组(Ⅱ组)显著升高(p<0.05)。甲基苯丙胺对其依赖人群的血管内皮功能有损害作用。
To investigate the effect of methamphetamine on the vascular endothelial function in people dependent on it, 50 cases of methamphetamine dependent group (Ⅰ) and 50 healthy people (Ⅱ group) were enrolled in this study. High-resolution vascular ultrasound was used to detect brachial artery Flow-mediated vasodilation (FMD), and blood levels of nitric oxide (NO) and endothelin-1 (ET-1). The levels of FMD and NO in methamphetamine dependent group (group Ⅰ) were significantly lower than those in healthy control group (Ⅱ) (p <0.05). The levels of endothelin-1 Compared with healthy control group (group Ⅱ), it was significantly higher (p <0.05). Methamphetamine has a detrimental effect on its vascular endothelial function dependent on the population.