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很久以来人们就已认识到,花生四烯酸及其环氧酶产物与过敏性慢反应物(SRS—A)和非免疫性产生的SRS类过敏介质之间有重要的相互作用。环氧酶抑制剂如乙酰水杨酸或消炎痛,在抗原刺激阶段抑制人或豚鼠肺前列腺素(PG)的产
It has long been recognized that there is an important interaction between arachidonic acid and its epoxidase products and allergic slow reactants (SRS-A) and non-immune SRS-like allergic mediators. Epoxide inhibitors, such as acetylsalicylic acid or indomethacin, inhibit the production of human or guinea pig lung prostaglandins (PG) during the antigen-stimulation phase