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目的探讨小睾丸症激素治疗的临床疗效。方法回顾分析从2000年3月～2006年3月,我院诊断为小睾丸症的66例患者。按性激素检测分为:(1)高促性腺激素组即促黄体激素(LH)和促卵泡成熟激素(FSH)升高,睾酮(T)水平低下组18例;(2)低促性腺激素组即LH、FSH和T水平低下组48例。低促性腺激素组使用人绒毛膜促性腺激素(HCG),人绝经期促性腺激素(HMG);高促性腺激素组使用安特尔,两组均治疗6个月。结果低促性腺激素组患者睾酮水平均升高或达到正常水平,第二性征改善,睾丸体积由治疗前的2～4ml增大到8～11ml,患者中2例获得生育,6例患者由于使用了HCG和HMG后出现乳房发育增大、胀痛,继而改用安特尔。高促性腺激素性组使用安特尔治疗后性欲改善,睾丸体积无增大。结论小睾丸症的发病机理较为复杂,根据不同类型分别采用HCG,HMG或睾酮联合应用是有效的治疗方法之一,但要达到正常男性化,需较长时间的持续治疗。
Objective To investigate the clinical effect of minor testicular steroid therapy. Methods From March 2000 to March 2006, 66 patients with minor testicular disease diagnosed in our hospital were retrospectively analyzed. The sex hormones were divided into: (1) high gonadotropin group that luteinizing hormone (LH) and follicle-stimulating hormone (FSH) increased, low testosterone group (18 cases); (2) low gonadotropin group That LH, FSH and T low level group of 48 patients. HGG used human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG), and high-gonadotropin group used Androtelol, both groups were treated for 6 months. Results The levels of testosterone in patients with low gonadotropin group were increased or reached the normal level, the second sexual characteristics were improved, the testicular volume increased from 2 ~ 4ml to 8 ~ 11ml before treatment, 2 cases were fertile, 6 cases After the use of HCG and HMG increased breast development, pain, and then switch to Anttel. Hypogonadotropin group after treatment with Andrides improved libido, testicular volume did not increase. Conclusion The pathogenesis of minor testicular syndrome is more complicated. It is one of the effective treatment methods according to different types of HCG, HMG or testosterone respectively. However, to achieve normal masculine, it takes a long time for continuous treatment.