论文部分内容阅读
临床上约80%的食管癌患者无手术指征,主要采用以放疗为主的综合疗法治疗[1]。食管癌的发生与基因突变有关,而相关基因表达与放疗预后密切相关。现将食管癌相关基因及其对放射治疗效果的影响概述如下。1 p53人的p53基因分为野生型及突变型,位于第17号染色体的短臂(17p13~17),转录长度为25 kb。野生型p53基因为抑癌基因,其编码的p53蛋白可调节细胞周期和DNA损伤后的凋亡,并可以促进基因毒性物质对DNA损伤后的修复。p53蛋白及基因存在于包括食管鳞癌在内的各种人类肿瘤组织
Clinically, about 80% of esophageal cancer patients have no indications for surgery, and they mainly use radiation therapy-based comprehensive therapy [1]. The occurrence of esophageal cancer is associated with gene mutations, and the expression of related genes is closely related to the prognosis of radiotherapy. The effects of esophageal cancer-related genes and their effects on radiation therapy are summarized below. 1 p53 human p53 gene is divided into wild type and mutant type, located in the short arm of chromosome 17 (17p13~17), the transcription length is 25 kb. The wild-type p53 gene is an anti-oncogene, and its encoded p53 protein can regulate cell cycle and apoptosis after DNA damage, and can promote the repair of DNA damage after a genotoxic substance. P53 protein and gene exist in various human tumor tissues including esophageal squamous cell carcinoma