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目前依据S区基因序列异质性大于或等于4%,将乙型肝炎病毒(HBV)分为A~H八种基因型[1,2],基因型反映HBV自然感染发生变异特点,是病毒变异进化的结果。越来越多的证据表明,HBV基因型可能与病毒感染途径、基因突变、疾病进程和抗病毒疗效具有一定相关性[3-5],且不同地区分布不一致?
Hepatitis B virus (HBV) is divided into A ~ H eight genotypes based on the gene sequence of the S region is greater than or equal to 4% [1,2], genotype reflects the characteristics of natural variation of HBV is characterized by virus Variation evolved the result. More and more evidences show that HBV genotypes may be related to virus infection, gene mutation, disease process and anti-virus curative effect [3-5], and inconsistent distribution in different regions?