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目的 :探讨不同病因的脑白质疏松症 (leukoaraiosis ,LA)患者听觉认知电位P3 0 0 的不同特征。方法 :选择 15 0例经CT或MRI诊断的LA患者 ,以及 40例正常健康老年人 (作为对照组 )。使用肌电诱发电位仪 ,以“听觉靶 非靶刺激序列”为诱发事件 ,完成P3 0 0 检测。结果 :15 0例LA患者中 ,37例不伴有其它疾病的老年患者较对照组靶和非靶刺激潜伏期N1、P2 、N2 和P3 虽然延长 ,P3 波幅降低 6 .3% ,但其差异均无显著性意义 (P >0 .0 5 ) ;39例伴有脑血管病危险因素的患者较对照组靶和非靶刺激潜伏期N1、P2 与对照组间的差异均无显著性意义 (P >0 .0 5 ) ,靶刺激潜伏期N2 、P3 均明显延长 ,P3 波幅降低 31.3% ;38例伴有脑血管病的LA患者和 36例伴有血管性痴呆的LA患者较对照组靶和非靶刺激潜伏期N1、P2 、N2 和P3 均明显延长 ,P3 波幅分别降低 48.4%和 6 0 .9%。结论 :P3 0 0 能够用于评价LA患者认知功能。
Objective: To investigate the different characteristics of auditory potential P3 0 0 in patients with leukoaraiosis (LA) of different etiologies. Methods: 150 patients with LA diagnosed by CT or MRI and 40 healthy controls were selected as the control group. The use of EMG potentiometer, “target auditory target non-target sequence” as the trigger event, complete P3 0 0 detection. Results: Among the 150 LA patients, the latency of target and non-target stimulation N1, P2, N2 and P3 were prolonged and the amplitude of P3 was decreased by 6.3% in 37 elderly patients without other diseases There was no significant difference between the control group and the control group (P> 0.05). There was no significant difference in the 39 patients with risk factors of cerebrovascular disease between the control group and the control group (P> 0.05). The latency of target stimulation was significantly prolonged in N2 and P3, and the amplitude of P3 was decreased by 31.3%. Compared with the control group, 38 patients with LA and 36 patients with LA accompanied with vascular dementia had higher The sensory latency N1, P2, N2 and P3 were significantly prolonged, P3 amplitude decreased 48.4% and 60.9%. Conclusion: P3 0 0 can be used to evaluate cognitive function in patients with LA.