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目的探索中国人群胃癌和吸烟的关系,并对不同性别和吸烟量进行亚组分析。方法所有数据来自中国期刊网全文数据库、维普数据、万方数据库、Science Direct和Pubmed医学数据库。统一制定文献评价标准,由两位研究者独立检索文献,独立对文献进行质量评价和提取信息。利用软件STATA中的Meta analysis模块进行统计分析。结果共纳入文献51篇(11260例病例)。在合计人群中,吸烟是胃癌发病的危险因素(OR=1.66,95%CI:1.47～1.87)。在男性中,吸烟是胃癌的危险因素(OR=1.93,95%CI:1.35～2.76),但在女性中却并未发现吸烟是胃癌的危险因素(OR=1.05,95%CI:0.67～1.64)。按吸烟量的不同,把吸烟分为轻度吸烟、中度吸烟、重度吸烟,通过Meta回归得到:LnOR=0.404×group-0.361,说明吸烟量每增加一个等级,胃癌的发病率会变为原来的1.5倍。结论吸烟是中国人群胃癌的危险因素之一,但在女性这种关系还需进一步研究。吸烟量不同对胃癌的发病率会产生影响。
Objective To explore the relationship between gastric cancer and smoking in Chinese population and analyze subgroups of different sex and smoking amount. Methods All data from the Chinese Journal Net full-text database, VIP data, Wanfang database, Science Direct and Pubmed medical database. Uniform standards for the development of documentation, the two researchers independently retrieve the literature, the independent quality evaluation of the literature and extract information. Statistical analysis was performed using the Meta analysis module in the software STATA. Results A total of 51 articles were included (11260 cases). Among the total population, smoking was a risk factor for gastric cancer (OR = 1.66, 95% CI: 1.47-1.87). In men, smoking was a risk factor for gastric cancer (OR = 1.93, 95% CI: 1.35-2.76) but smoking was not found to be a risk factor for gastric cancer in women (OR = 1.05, 95% CI: 0.67 to 1.64 ). According to the amount of smoking, the smoking is divided into mild smoking, moderate smoking, heavy smoking, obtained by Meta regression: LnOR = 0.404 × group-0.361, indicating that every increase in smoking levels, the incidence of gastric cancer will become the original 1.5 times. Conclusions Smoking is one of the risk factors for gastric cancer in Chinese population. However, this relationship needs further study in women. Different amounts of smoking on the incidence of gastric cancer will have an impact.