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环维黄杨星Ｄ（ＣＶＢ－Ｄ）１～１０μｍｏｌ／Ｌ和哇巴因合用后，离体豚鼠心肌收缩力增强，收缩和舒张时间缩短，平均收缩速度和舒张速度加快，最大反应增加。 ＣＶＢ－Ｄ１～１０ｕｍｏｌ／Ｌ增强异丙肾上腺素、去氧肾上腺素、组胺和 ＣａＣｌ２的正性肌力作用，使其量效曲线左移，最大反应增加。 ＣＶＢ－Ｄ能对抗维拉帕米和 Ａｃｈ５ｕｍｏｌ／Ｌ所致的负性肌力作用。结果表明，ＣＶＢ－Ｄ正性肌力作用的机理可能与 ａ、β和 Ｈ２－受体、电压依赖钙通道激动剂及哇巴因不同，而与促进心肌细胞外Ｃａ２＋内流和抑制内Ｋ＋外流有关。
Contractile force of contractile and diastolic myocardium in isolated guinea pigs was enhanced after co-administration of CVB-D 1 ~ 10μmol / L and ouabain, and systolic and diastolic time was shortened. The average systolic and diastolic velocities were increased and the maximum response was increased. CVB-D1 ~ 10umol / L enhances the positive inotropic effect of isoproterenol, phenylephrine, histamine and CaCl2, and shifts the dose-response curve to the left and the maximal response increases. CVB-D is able to combat negative inotropic effects caused by verapamil and Ach5umol / L. The results showed that the mechanism of positive inotropic action of CVB-D may be different from that of a, β and H2-receptors, voltage-dependent calcium channel agonists and ouabain, but not with promoting intracellular Ca2 + influx and inhibiting intracellular K + efflux related.