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双异丙吡胺的应用日益增多,出现了一些应用过量的病例,常导致致死性的严重中毒反应。心肌抑制可能是致死的一个重要原因,可有低血压、快速与缓慢性心律失常、意识障碍、呼吸抑制和惊厥等。本文报道用狗进行双异丙吡胺毒性研究,以此作为一种模型,以观察其中毒的病理学后果,并提出合理的处理方法。方法:对8条狗(平均体重14.6公斤)进行了13次试验。在戊巴比妥麻醉下作股动脉插管以持续监测体循环动脉压。3条狗并用 Swan Ganz导管监测肺动脉压和左心房(肺动脉楔嵌)压。用热
The use of DDI is increasing, with some cases of overdose, often leading to fatal severe toxic reactions. Myocardial inhibition may be an important cause of death, may have hypotension, rapid and bradyarrhythmia, disturbance of consciousness, respiratory depression and convulsions. This article reports the study of DDB toxicity in dogs as a model to observe the pathological consequences of poisoning and to propose reasonable treatment methods. Methods: Thirteen trials were conducted on eight dogs (mean body weight 14.6 kg). Intubation of femoral artery under pentobarbital anesthesia to continuously monitor systemic arterial pressure. Three dogs were monitored for pulmonary artery pressure and left atrium (pulmonary artery wedge pressure) using a Swan Ganz catheter. With heat