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钙粘蛋白家族(cadherin family)是一个超家族,均为钙依赖的单链跨膜糖蛋白,主要介导同型细胞间的粘附。目前,上皮细胞钙粘蛋白(epithelial cells cadherin,E-cad)成为研究热点之一,它与上皮恶性肿瘤的分级、侵袭、转移和预后相关,可用于肿瘤的诊断、鉴别诊断、疗效监测和预后判断。E-cad与白血病的相关性也越来越受到重视,与白血病细胞的浸润和转移有关。本文就E-cad在白血病中的表达及其与中枢神经系统白血病的关系的研究进展作一综述。
The cadherin family is a superfamily of calcium-dependent single-stranded transmembrane glycoproteins that primarily mediate islet cell adhesion. Currently, epithelial cell cadherin (E-cad) has become one of the hot spots of research. It is associated with the grade, invasion, metastasis and prognosis of epithelial malignant tumors. It can be used in tumor diagnosis, differential diagnosis, curative effect monitoring and prognosis judgment. E-cad and leukemia is also more and more attention, and leukemia cells invasion and metastasis. This article reviews the research progress of E-cad expression in leukemia and its relationship with central nervous system leukemia.