维蒂希试剂(Wittig)通常以四级磷盐在强碱作用下失去一分子卤化氢制备,而磷盐则可由三苯基磷和卤代烃反应得到。前者制备反应通常在乙醚或四氢呋喃中进行,强碱选用苯基锂或正丁基锂,反应收率一般,本文介绍了一种合成维蒂希试剂(Wittig)的新方法,利用该醇类有机物,如甲醇或乙醇的同系物,与三苯基磷和48%的溴化氢水溶液共同作用生成接近定量收率的烷基三苯基磷盐,进一步反应生成格式试剂,收率较高,反应操作简单,适合工业化生产。 Wittig is usually prepared by the loss of one molecule of hydrogen halide from a quaternary phosphonium salt under the action of a strong base, while the phosphorus salt can be obtained from the reaction of triphenylphosphine and a halogenated hydrocarbon. The former preparation reaction is usually carried out in ether or tetrahydrofuran, strong base selection with phenyl lithium or n-butyllithium, the reaction yield in general, this article describes a new method for the synthesis of Wittig reagent (Wittig), the use of the alcoholic organics , Such as methanol or ethanol homologues, together with triphenylphosphine and 48% aqueous hydrogen bromide to produce nearly quantitative yield of alkyl triphenyl phosphate salt, and further reaction to generate the format reagent, a higher yield, the reaction Simple operation, suitable for industrial production.