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目的研究宫腔镜电切术联合口服孕激素及宫内放置左炔诺孕酮宫内缓释系统(LNG-IUS)治疗早期子宫内膜癌的效果。方法 20例早期子宫内膜癌患者,随机分成对照组与研究组,每组10例。所有患者均行宫腔镜电切术治疗,对照组患者给予口服孕激素治疗,研究组患者给予口服孕激素及宫内放置LNG-IUS治疗。观察并对比两组患者缓解、复发、术后妊娠及不良反应发生情况。结果两组患者治疗后缓解及复发情况比较差异无统计学意义(P>0.05)。两组患者妊娠及不良反应发生情况比较差异均无统计学意义(P>0.05)。研究组患者妊娠时间(15.3±5.4)个月、缓解时间(9.4±1.7)个月均短于对照组(21.5±6.2)个月、(11.8±2.2)个月,差异均具有统计学意义(P<0.05)。结论在早期子宫内膜癌患者治疗中选择宫腔镜电切术联合口服孕激素及宫内放置LNG-IUS治疗可加速患者康复,具有一定的安全性和可行性,值得在临床上推广使用。
Objective To study the effect of hysteroscopic electrotomy combined with oral progestin and intrauterine delivery of levonorgestrel intrauterine system (LNG-IUS) in the treatment of early endometrial cancer. Methods Twenty patients with early endometrial cancer were randomly divided into control group and study group, with 10 cases in each group. All patients underwent hysteroscopic resection, patients in the control group received oral progestin, and patients in the study group received oral progestin and intrauterine LNG-IUS treatment. Observe and compare the two groups of patients with remission, recurrence, postoperative pregnancy and adverse reactions. Results There was no significant difference in remission and relapse between the two groups after treatment (P> 0.05). There was no significant difference in pregnancy and adverse reactions between the two groups (P> 0.05). The study group’s pregnancy time (15.3 ± 5.4) months, the remission time (9.4 ± 1.7) months were shorter than the control group (21.5 ± 6.2) months, (11.8 ± 2.2) months, the differences were statistically significant P <0.05). Conclusion In the treatment of early endometrial cancer patients choose hysteroscopic resection combined with oral progesterone and intrauterine placement of LNG-IUS therapy can speed up the rehabilitation of patients with a certain safety and feasibility, it is worth to promote the use of the clinic.