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用胰管内加压注射自身胆汁和胰蛋白酶溶液的方法造成狗实验性出血坏死性胰腺炎,观察了血清、肺淋巴液和肺组织血管紧张素转化酶(ACE)与肺淋巴流量、肺跨血管蛋白清除率的动态变化。结果发现,注射后混合静脉血ACE活性持续下降,动脉血ACE活性出现一过性升高而后又降低,肺淋巴液ACE活性升高,肺组织ACE活性降低。在血清和肺淋巴液ACE活性变化的同时,肺淋巴流量和肺跨血管蛋白清除率增加2～3倍。动物死后解剖,肺有明显水肿、出血和局灶性肺不张。实验结果提示,测定血清ACE活性可反映肺血管内皮细胞的受损情况,作为早期诊断肺损伤的一项有用指标。
Experimental bolus hemorrhagic necrotizing pancreatitis was induced by injecting bile and trypsin solution into the pancreatic duct autonomously. Angiotensin-converting enzyme (ACE) and pulmonary lymphocyte flux were observed in serum, lung lymph and lung tissue, Dynamic changes of protein clearance. The results showed that ACE activity in mixed venous blood continued to decrease after injection, transiently increased ACE activity in arterial blood and then decreased, ACE activity in lung lymph fluid increased, and ACE activity in lung tissue decreased. In the serum and lung lymph ACE activity changes at the same time, pulmonary lymph flow and pulmonary vascular protein clearance increased by 2 to 3 times. Anatomy of the animal after death, significant pulmonary edema, bleeding and focal atelectasis. Experimental results suggest that determination of serum ACE activity can reflect the damage of pulmonary vascular endothelial cells as a useful indicator of early diagnosis of lung injury.