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目的研究评价HIV感染患者进行高效抗逆转录病毒治疗脑部功能区变化。方法采用Siemens 3.0 T磁共振成像系统进行受试者扫描。HIV感染患者45例,已行高效抗逆转录病毒治疗22例,未行治疗23例。实验任务为组块设计的双侧手部运动试验。通过SPM8软件对实验进行数据预处理及统计学分析,经过组内数据统计及组间数据比较分析,获取正常受试者和HIV感染者及治疗患者分组间脑部激活功能区差异。结果 HIV患者组中经抗病毒治疗患者左手运动任务激活区与未进行治疗患者间差异无统计学意义,治疗患者执行右手运动任务激活区包括左侧中央前回、中央后回、辅助运动皮层及右侧小脑均出现激活,未治疗患者在右侧颞极、海马及左侧小脑激活程度高于治疗后患者。结论高效抗逆转录病毒治疗有效抑制了部分脑区的异常激活,为治疗HIV侵入中枢神经系统及损伤机制提供新的方法。
Objective To evaluate the changes of brain functional areas in patients with HIV infection by highly effective antiretroviral therapy. Methods Subjects were scanned using the Siemens 3.0 T magnetic resonance imaging system. 45 cases of HIV-infected patients, 22 cases have been highly effective antiretroviral therapy, 23 cases without treatment. The experimental task is a two-sided hand motion test designed for chunks. Data preprocessing and statistical analysis were carried out on the experiment through SPM8 software. After statistical analysis of the data in the group and comparative analysis of the data between groups, the differences of brain activation functional groups between the normal subjects and the HIV infected persons and the treatment group were obtained. Results There was no significant difference between the patients with HIV and the untreated patients who underwent active left-handed exercise and those without active treatment. The activation of right-handed patients in the HIV patients group included the left central anterior gyrus, the central posterior gyrus, the motor cortex and the right The activation of the lateral cerebellum occurred. The untreated patients had more activation in the right temporal pole, hippocampus and left cerebellum than those in the treated group. Conclusion Highly effective antiretroviral therapy effectively inhibits the abnormal activation of some brain regions and provides a new method for the treatment of HIV invasion of the central nervous system and its mechanism of injury.