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3-乙酰基吡啶经二溴代、与多聚甲醛/氨水作用环合制得4-(3-吡啶基)-1H-咪唑,再与N-(4-溴丁基)邻苯二甲酰亚胺缩合、肼解制得泰利霉素侧链4-[4-(3-吡啶基)-1H-咪唑基]-1-丁胺,总收率约41%。
3-Acetylpyridine is cyclized with dibromo-substituted paraformaldehyde / ammonia to give 4- (3-pyridyl) -1H-imidazole which is then coupled with N- (4-bromobutyl) phthaloyl Imine condensation, hydrazinol side chain telithromycin 4- [4- (3-pyridyl) -1H-imidazolyl] -1-butylamine, the total yield of about 41%.