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目的分析维吾尔族、汉族人群血清视黄醇结合蛋白4(RBP4)在非酒精性脂肪肝病(NAFLD)患者中的水平,探讨血清RBP4与NAFLD的相关性。方法采用病例-对照研究的方法选择维吾尔族、汉族NAFLD患者各200名为病例组,维吾尔族、汉族健康者各200名为对照组,检测体重指数(BMI)、血压、生化指标以及血清RBP4浓度。采用Spearman相关分析,分析RBP4与NAFLD发生率的相关性;采用Pearson相关分析,研究RBP4与BMI、收缩压(SBP)、收缩压(DBP)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血尿酸(SUA)、谷草转氨酶(AST)、丙氨酸氨基转移酶(ALT)的相关性,采用非条件logistic回归分析NAFLD的影响因素。结果维吾尔族、汉族人群NAFLD组RBP4浓度显著高于对照组(P<0.01),NAFLD组维吾尔族RBP4浓度显著高于汉族(P<0.01)。两个民族RBP4水平与NAFLD发病率均呈正相关(P<0.001);维吾尔族人群RBP4浓度与BMI、FPG、TG、HDL、SUA、AST及ALT呈正相关性,汉族人群RBP4浓度与BMI、FPG、血压、TG、TC、HDL、SUA、AST以及ALT呈正相关性,非条件logistic回归分析显示维吾尔族人群、汉族人群中RBP4浓度为NAFLD的危险因素。结论维吾尔族、汉族人群NAFLD患者血清RBP4水平明显升高,血清RBP4水平与NAFLD患病相关,是NAFLD的危险因素之一。
Objective To analyze the level of serum retinol binding protein 4 (RBP4) in patients with non-alcoholic fatty liver disease (NAFLD) in Uygur and Han ethnic groups and explore the correlation between serum RBP4 and NAFLD. Methods A case-control study was conducted in 200 Uygur and Han nationality NAFLD patients. 200 Uygur and 200 Han healthy subjects were selected as the control group. Body mass index (BMI), blood pressure, biochemical parameters and serum RBP4 concentration . Spearman correlation analysis was used to analyze the correlation between the incidence of NAFLD and RBP4. Pearson correlation analysis was used to investigate the correlation between RBP4 and BMI, SBP, FPG, TG, (TC), HDL, LDL, SUA, AST and ALT were determined by using non-conditional Logistic regression analysis of the influencing factors of NAFLD. Results The concentration of RBP4 in NAFLD group was significantly higher than that in control group (P <0.01). The concentration of RBP4 in NAFLD group was significantly higher than that of Han population (P <0.01). There was a positive correlation between RBP4 levels and the incidence of NAFLD in both ethnic groups (P <0.001). There was a positive correlation between RBP4 concentration and BMI, FPG, TG, HDL, SUA, AST and ALT in Uighur population, Blood pressure, TG, TC, HDL, SUA, AST and ALT were positively correlated. Non-conditional logistic regression analysis showed that the concentration of RBP4 was the risk factor for NAFLD in Uygur and Han nationality. Conclusions Serum RBP4 levels are significantly increased in NAFLD patients from Uygur and Han nationalities. Serum RBP4 level is associated with the prevalence of NAFLD, which is one of the risk factors for NAFLD.