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目的观察鸦胆子油乳注射液联合DP化疗方案治疗中晚期非小细胞肺癌的临床疗效。方法选取梧州市工人医院血液肿瘤科2010年1月—2015年6月收治的中晚期非小细胞肺癌患者76例,按照就诊时间排序,序列号为单号患者作为观察组,序列号为双号患者作为对照组,各38例。观察组给予鸦胆子油乳注射液联合DP化疗方案,对照组单独应用DP化疗方案,4个化疗周期后观察两组患者的临床疗效、肿瘤直径及毒副作用发生情况。结果观察组患者总有效率为89.5%,高于对照组的76.3%,差异有统计学意义(P<0.05)。治疗前两组患者肿瘤直径比较,差异无统计学意义(P>0.05);治疗后观察组肿瘤直径小于对照组,差异有统计学意义(P<0.05)。两组患者均有不同程度的骨髓抑制、消化道反应、脱发、肝肾功能损害、外周神经毒性等毒副作用,但两组各毒副作用发生率比较,差异无统计学意义(P>0.05)。结论鸦胆子油乳注射液联合DP化疗方案治疗中晚期非小细胞肺癌疗效确切,且不会增加患者的毒副作用,安全可靠。
Objective To observe the clinical effect of Brucea javanica oil emulsion combined with DP chemotherapy in the treatment of advanced non-small cell lung cancer. Methods 76 cases of advanced non-small cell lung cancer were enrolled in the Department of Hematology and Oncology, Wuzhou Workers Hospital from January 2010 to June 2015. According to the time of treatment, the patients whose sequence number was single were regarded as the observation group and the serial number was double Patients as a control group, 38 cases each. The observation group was treated with Brucea javanica oil injection combined with DP chemotherapy. The control group received DP chemotherapy alone. The clinical efficacy, tumor diameter and toxicities and side effects of the two groups were observed after 4 cycles of chemotherapy. Results The total effective rate in observation group was 89.5%, which was higher than that in control group (76.3%), the difference was statistically significant (P <0.05). There was no significant difference in tumor diameter between the two groups before treatment (P> 0.05). After treatment, the tumor diameter in observation group was smaller than that in control group (P <0.05). Both groups had different degrees of myelosuppression, gastrointestinal reactions, hair loss, liver and kidney dysfunction, peripheral nerve toxicity and other side effects, but there was no significant difference in the incidence of side effects between the two groups (P> 0.05). Conclusion Brucea javanica oil injection combined with DP chemotherapy regimen in the treatment of advanced non-small cell lung cancer is effective, and does not increase the side effects of patients, safe and reliable.