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目的观察地塞米松局部注射治疗桥本甲状腺炎的临床疗效。方法 68例桥本甲状腺炎患者,随机分为实验组和对照组,各34例。实验组给予地塞米松注射液局部注射治疗,对照组未予任何处置。用药8周后及停药后8周所有患者化验甲状腺功能,对比两组甲状腺过氧化物酶抗体(TPO-Ab)及甲状腺球蛋白抗体(Tg-Ab)下降的程度,并观察患者临床症状消失比例、复发情况。结果用药8周后实验组TPO-Ab、Tg-Ab较对照组下降明显(P<0.05);实验组31例在治疗3~4周左右颈部不适消失,对照组12例在6~8周左右颈部不适消失,比较差异有统计学意义(P<0.05)。停药后实验组1例复发,少于对照组的10例(P<0.05)。结论实验组甲状腺过氧化物酶下降明显,且局部注射治疗患者临床症状改善明显,副作用小,复发率低。
Objective To observe the clinical effect of local injection of dexamethasone on Hashimoto’s thyroiditis. Methods 68 patients with Hashimoto’s thyroiditis were randomly divided into experimental group and control group, with 34 cases in each. Experimental group given dexamethasone injection of local injection treatment, the control group without any treatment. After 8 weeks and 8 weeks after drug administration, all patients were tested for thyroid function, and the levels of thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (Tg-Ab) in the two groups were compared and the clinical symptoms disappeared Proportion, recurrence. Results The levels of TPO-Ab and Tg-Ab in the experimental group decreased significantly (P <0.05) 8 weeks after treatment. In the experimental group, 31 cases were relieved of cervical discomfort about 3 to 4 weeks after treatment, while those in the control group were 6 to 8 weeks Left and right neck discomfort disappeared, the difference was statistically significant (P <0.05). One patient in the experimental group relapsed after stopping the treatment, less than 10 in the control group (P <0.05). Conclusion The thyroid peroxidase in the experimental group decreased obviously, and the clinical symptoms of the patients treated with local injection improved obviously with less side effects and lower recurrence rate.