热休克蛋白７０（ＨＳＰ７０）是高度保守的蛋白，具有免疫原性，能诱导特异性免疫反应。免疫反应主要发生于其碳末端的抗原决定簇，而不同物种间此段的蛋白质序列差异也最大。在某些内耳疾病如特发性进行性双侧感音神经性耳聋（ＩＰＢＳＮＨＬ）和梅尼埃病中，ＨＳＰ７０... Heat shock protein 70 (HSP70) is a highly conserved protein that is immunogenic and induces specific immune responses. The immune response mainly occurs at the carbon end of the antigenic determinant, and the difference in protein sequence between different species is the largest. In certain inner ear diseases such as idiopathic progressive bilateral sensorineural hearing loss (IPBSNHL) and Meniere’s disease, HSP70