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目的:研究吴茱萸对黄连中小檗碱和巴马汀在大鼠肠道吸收中的影响及其机制。方法:采用大鼠单向肠灌流模型,考察维拉帕米和吴茱萸提取物对小檗碱和巴马汀在各肠段吸收的影响,利用HPLC分别测定小檗碱和巴马汀的量,计算两种生物碱的肠吸收速率常数(Ka)和表观吸收系数(Papp)。结果:黄连提取物和吴茱萸提取物配比为6∶12时小檗碱和巴马汀的Ka和Papp显著增加。黄连生物碱单体化合物小檗碱、巴马汀与吴茱萸提取物6∶12配伍时,能明显促进小檗碱和巴马汀的吸收;6∶1配伍时,减弱小檗碱的吸收,促进巴马汀的吸收。P-糖蛋白(P-gp)抑制剂维拉帕米的存在均能促进小檗碱和巴马汀的吸收。结论:黄连配伍吴茱萸可促进黄连中小檗碱和巴马汀的肠吸收,其机制可能与抑制P-gp的活性有关。
Objective: To study the effect of Evodia on the intestinal absorption of berberine and palmatine in rats and its mechanism. Methods: The unilateral intestinal perfusion model was used to investigate the effects of verapamil and Evodia rutaecarpa extract on the absorption of berberine and palmatine in various intestine segments. The contents of berberine and palmatine were determined by HPLC. The intestinal absorption rate constant (Ka) and apparent absorption coefficient (Papp) of the two alkaloids were calculated. Results: Ka and Papp of berberine and palmatine were significantly increased when the ratio of Coptidis Rhizoma and Fructus Evodiae extract was 6:12. Coptis alkaloids monomer compounds berberine, palmatine and Evodia extract 6:12 compatibility, can significantly promote the absorption of berberine and palmatine; 6: 1 compatibility, weaken the absorption of berberine and promote Absorption of palmatine. The presence of verapamil, a P-glycoprotein (P-gp) inhibitor, can both promote the absorption of berberine and palmatine. CONCLUSION: Coptis chinensis Franch and Evodia rutaecarpa can promote the intestinal absorption of berberine and palmatine in Coptis chinensis, and its mechanism may be related to the inhibition of the activity of P-gp.