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业已合成了一系列的化合物,并发现此类化合物具有消炎镇痛样的和左旋咪唑样的双重活性的消炎剂,鉴于其药理特性故选择此系列化合物中的Prinomide作进一步的评价。合成本品是按EP 143142所述方法由N-甲基吡咯-2-羧酸经数步反应合成而得。药理本品是一个新的非甾族消炎镇痛药,具有免疫调节活性,经小鼠中体外和体内试验的数据表明,迟发型超敏反应、抗体的水平是与药物剂量,以及相关性反应在小鼠和
A series of compounds have been synthesized and found to have dual anti-inflammatory and analgesic-like and levamisole-like anti-inflammatory agents. For their pharmacological properties, Prinomide in this series of compounds was selected for further evaluation. The synthesis of this product is based on the method described in EP 143142 from N-methylpyrrole-2-carboxylic acid synthesis by several steps derived. Pharmacology This product is a new non-steroidal anti-inflammatory analgesic with immunomodulatory activity. The data from in vitro and in vivo experiments in mice indicate that delayed type hypersensitivity and antibody levels are related to the dose of the drug and the associated response In mice and