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为了解在强制戒毒过程中，外周血自然杀伤细胞（ＮＫＣ）活性及单个核细胞分泌的ＩＬ－２ 活性变化，以及外周血清中ＩＬ－６ 及肿瘤坏死因子α（ＴＮＦα）水平的变化，对５１ 例吸毒成瘾者采用生物活性测定法（ＭＴＴ）测定了ＮＫＣ活性及ＩＬ－２活性，用ＥＬＩＳＡ法测定了外周血清中ＩＬ－６ 及ＴＮＦα水平。结果：海洛因依赖者ＮＫＣ３０．１１±５．２％ ；ＩＬ－２ ８．０６±１．６６ＩＵ／ｍ ｌ；ＩＬ－６ ６１．１７±１２．０７ｐｇ／ｍ ｌ；ＴＮＦα９１．８３±１９．１９ｐｇ／ｍ ｌ。正常对照上述各项指标分别为４４．８９±４．７５％ ，１５．９１±３．８３ＩＵ／ｍ ｌ，２２．１８±９．３１ｐｇ／ｍ ｌ，３０．５５±１１．９４ｐｇ／ｍ ｌ。经强制戒毒后ＮＫＣ和ＩＬ－２ 活性及ＩＬ－６ 和ＴＮＦα水平逐渐恢复正常，与戒毒时间呈明显相关。
To understand the changes of natural killer cell (NKC) activity in peripheral blood and IL-2 secretion secreted by mononuclear cells and the changes of IL-6 and TNFα levels in peripheral blood during compulsory treatment, In the case of drug addicts, NKC activity and IL-2 activity were measured by bioactivity assay (MTT). The levels of IL-6 and TNFα in peripheral blood serum were determined by ELISA. Results: The heroin addicts NKC 30.11 ± 5.2%; IL-2 8.06 ± 1.66 IU / ml; IL-6 61.17 ± 12.07 pg / ml; TNFα 91.83 ± 19.19 pg / m l. The above indicators of the normal control were 44.89 ± 4.75%, 15.91 ± 3.83IU / ml, 22.18 ± 9.31pg / ml, 30.55 ± 11.94pg / ml, respectively. The NKC and IL-2 activity and the levels of IL-6 and TNFα gradually returned to normal after compulsory drug treatment, and were significantly correlated with the time of detoxification.