论文部分内容阅读
目的:观察亚低温治疗颅脑爆震伤患者继发脑梗死的疗效。方法:选择颅脑爆震伤后脑梗死52例,随机分为对照组23例和观察组29例。对照组采用临床常规治疗,观察组在对照组治疗基础上加用亚低温治疗。观察比较两组疗效、神经功能缺损评分,以及白细胞介素-1(IL-1)、肿瘤坏死因子α(TNF-α)水平变化情况。结果:观察组总有效率79.3%,显著高于对照组的47.8%(P<0.05)。治疗前两组神经功能缺损分值均差异不显著(P>0.05),治疗后两组神经功能缺损分值显著低于治疗前(P<0.05);同时观察组治疗后神经功能缺损分值显著低于对照组治疗后(P<0.05)。两组急性期IL-1、TNF-α水平差异不显著(P>0.05),恢复期IL-1、TNF-α水平显著低于同组急性期;同时观察组恢复期IL-1、TNF-α水平显著低于对照组恢复期(P<0.05)。结论:常规加亚低温治疗颅脑爆震伤患者继发脑梗死疗效优于常规治疗。
Objective: To observe the efficacy of mild hypothermia in patients with craniocerebral blast injury secondary to cerebral infarction. Methods: 52 cases of cerebral infarction after craniocerebral injury were randomly divided into control group (n = 23) and observation group (n = 29). The control group was treated with routine clinical treatment. The observation group was treated with mild hypothermia on the basis of the control group. The curative effect, neurological deficit score and the levels of interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) in the two groups were observed and compared. Results: The total effective rate in the observation group was 79.3%, significantly higher than that in the control group (47.8%, P <0.05). There was no significant difference in neurological deficit score between the two groups before treatment (P> 0.05). After treatment, the neurological deficit scores of the two groups were significantly lower than those before treatment (P <0.05); meanwhile, the score of neurological deficit in the observation group was significant Lower than the control group after treatment (P <0.05). The levels of IL-1 and TNF-α in acute phase of the two groups were not significantly different (P> 0.05), while the levels of IL-1 and TNF- α levels were significantly lower than the control group recovery (P <0.05). Conclusion: The curative effect of conventional plus mild hypothermia on patients with craniocerebral blast injury after cerebral infarction is better than that of routine treatment.