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目的比较替勃龙与雌二醇屈螺酮在治疗妇女绝经后相关症状的疗效。方法选取从2015年8月-2016年3月就诊于上海交通大学附属第六人民院更年期门诊的40~60岁的绝经后妇女作为研究对象,分成替勃龙组40例和雌二醇屈螺酮组25例,分别给予替勃龙2.5 mg,口服,每日1次和雌二醇屈螺酮(雌二醇1.0 mg+屈螺酮2.0 mg)口服,每日1次,疗程均为6个月,采用MRS量表、PSQI量表评价治疗前治疗后绝经症状及睡眠质量,并记录用药期间不良反应。结果两组治疗后MRS评分、PSQI评分的总分均明显降低,差异均有显著的统计学意义(P<0.01)。对睡眠障碍的治疗效果,替勃龙能在较短时间内得到明显效果,用药1个月,有50%以上的患者睡眠可改善到正常。两组在用药1个月、3个月、6个月都对潮热流汗、心脏不适、睡眠失常、身体或精神疲惫的改善比较明显,差异有统计学意义(P<0.05)。两组均无明显的不良反应发生。结论替勃龙和雌二醇屈螺酮治疗围绝经期出现的各种症状总体上疗效相当。但在易怒、焦虑、膀胱不适、情绪低落、阴道干涩、睡眠障碍等方面替勃龙能在较短时间内得到明显效果。
Objective To compare the efficacy of tibolone and estradiol drospirenone in treating postmenopausal symptoms in women. Methods From August 2015 to March 2016, 40 to 60-year-old postmenopausal women treated in the Menopause Clinic of the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University were enrolled in this study. Ketone 25 patients were given tibolone 2.5 mg, orally, once daily and drospirenone estradiol (estradiol 1.0 mg + drospirenone 2.0 mg) orally, once daily for 6 courses Month, using the MRS scale, PSQI scale to evaluate pre-treatment postmenopausal symptoms and quality of sleep, and record adverse reactions during the treatment. Results The total score of MRS score and PSQI score after treatment in both groups were significantly decreased, the differences were statistically significant (P <0.01). The treatment of sleep disorders, tibolone can be significantly shorter period of time, medication 1 month, more than 50% of patients with sleep can be improved to normal. The improvement of hot flashes, heart discomfort, sleep disorders, physical or mental fatigue in both groups at one month, three months and six months were statistically significant (P <0.05). No adverse reactions occurred in both groups. Conclusion TBA and drospirenol estradiol treat peri-menopausal symptoms of various symptoms generally have the same effect. But in the irritability, anxiety, bladder discomfort, depression, vaginal dryness, sleep disorders and other aspects of tibolone can be obtained in a relatively short period of time obvious effect.