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在同一石棉纺织厂工作的37名石棉肺病人及接触石棉而无肺纤维化的37名对照工人中测定了 HLA 抗原。此两组间或每一组与未曾接触过石棉的对照组之间的抗原出现率无显著差异。此资料与其它小型试验性调查的资料作比较时,未证实已往提出的石棉肺与 HLA—B_(27)的关系。HLA—B_(12)阳性的受检者。X 线照片倾向于重症纤维化。没有肺纤维化的石棉工人 HLA—BW_5有意想不到的高出现率,可能表示此种抗原防止了肺纤维化的进展。
HLA antigens were determined in 37 asbestosis patients working in the same asbestos mill and 37 control workers exposed to asbestosis without pulmonary fibrosis. There was no significant difference in antigen appearance between these two or each group and the control group that had not been exposed to asbestos. This data compared with other small pilot survey data, did not confirm the previously proposed asbestosis of lung and HLA-B_ (27) of the relationship. HLA-B_ (12) positive subjects. X-rays tend to be severe fibrosis. The unexpected high incidence of HLA-BW_5 in asbestos workers without pulmonary fibrosis may indicate that such antigens prevent the progression of pulmonary fibrosis.