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脓毒症的发生发展过程与炎症反应、凝血及抗凝过程和免疫功能紊乱等密切相关。由组织因子(TF)所启动的外源性凝血途径不仅在脓毒症凝血反应中起关键作用,而且在炎症反应中也起着重要的作用。而组织因子途径抑制物(TFP I)则为外源性凝血过程的重要负性调节物。研究表明,TF和TFP
The occurrence and development of sepsis and inflammation, coagulation and anticoagulation process and immune dysfunction is closely related. Exogenous coagulation pathways initiated by tissue factor (TF) not only play a key role in the coagulation reaction of sepsis but also play an important role in the inflammatory response. Tissue factor pathway inhibitor (TFPI) is an important negative regulator of extrinsic coagulation. Research shows that TF and TFP