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心血管疾病发生率和致死率逐年增加,而目前的治疗手段仍不足以解决这一现状。Ca~(2+)是重要的第二信使,其稳态失衡会导致细胞功能障碍和代谢紊乱,从而引起心脏功能异常,如心肌肥厚、心房纤颤、心肌缺血与心力衰竭等心血管疾病。兰尼碱受体2(RyR2)、L型钙通道(LTCC)、钠钙交换体(NCX)以及腺苷三磷酸(ATP)依赖性钙泵(SERCA2a)等均能参与钙稳态的维持,然而更确切的调控机制仍未完全阐明,导致其在心血管疾病治疗与预防应用中存在局限。非编码核糖核酸(ncRNA)是一类不编码蛋白的核糖核酸(RNA),可参与多种生物学功能。阐明非编码RNA在钙稳态过程中的调控机制,有助于预测心房颤动等心脏疾病易感性、延缓病情进展及评估预后。本文对非编码RNA参与心脏疾病钙稳态调控机制研究进展进行综述。
The incidence of cardiovascular diseases and fatality rate increase year by year, but the current treatment is still not enough to solve this situation. Ca ~ (2+) is an important second messenger whose homeostatic imbalance leads to cellular dysfunction and metabolic disorders, leading to cardiac dysfunction such as cardiovascular diseases such as cardiac hypertrophy, atrial fibrillation, myocardial ischemia and heart failure . RyR2, LCCC, NCX and SERCA2a all participate in the maintenance of calcium homeostasis, However, a more exact regulation mechanism has not yet been fully elucidated, leading to its limitations in the treatment and prevention of cardiovascular diseases. Non-coding RNA (ncRNA) is a class of non-coding protein ribonucleic acid (RNA), can participate in a variety of biological functions. To elucidate the regulatory mechanism of non-coding RNA in the process of calcium homeostasis, it is helpful to predict the susceptibility of heart diseases such as atrial fibrillation, delay the progression of the disease and evaluate the prognosis. This review summarizes the progress of non-coding RNA involved in calcium homeostasis in cardiac diseases.