冬季严寒时期,对发生在野外现场的伤病员,常因急救用注射液发生冻结或析出冰结晶而影响抢救工作,使注射药的现场应用受到限制。我们根据实际需要,对注射液抗冻溶媒进行了筛选和安全实验,证实40%二甲亚砜溶液具有明显的抗冻作用,性质稳定,使用安全。我们用抗冻溶媒制备了抗冻普鲁卡因注射液,实验表明同普鲁卡因注射液具有相同的局部麻醉效果,且无副作用。现简报如下。 Winter cold period, the occurrence of the scene in the wounded and sick, often because of emergency injection occurred freezing or precipitation of ice crystals and affect the rescue work, so that the field of injection of drug application is limited. According to the actual needs of our antifreeze injection media screening and safety experiments confirmed that 40% dimethylsulfoxide solution has obvious antifreeze, stable, safe to use. We prepared antifreezing procaine injection with antifreeze vehicle and the experiment showed that it had the same local anesthetic effect as procaine injection with no side effects. Now briefing as follows.