【摘 要】
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Dear Editor,rnβ-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5％of the global population (Origa, 2017).
【机 构】
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College of Veterinary Medicine Key Laboratory of Comprehensive Prevention and Control for Severe Cli
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Dear Editor,rnβ-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5％of the global population (Origa, 2017). In southern China, the car-rier rate of β-thalassemia is as high as 6.43％, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin:HbA1 (～97％), HbA2 (～2％) and HbF (～1％). HbA1 (α2β2) is composed of twoα-globin and twoβ-globin subunits encoded by HBA and HBB, respectively; HbF (α2γ2) is made up of two α-globin subunits and two γ-globin subunits encoded by HBG.
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