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从红树角果木内生真菌Penicillium herquei JX4中分离纯化得到11个次级代谢产物,应用质谱(MS)、核磁共振(NMR)以及圆二色谱(ECD)等多种波谱和光谱技术确定了11个次级代谢产物的结构,经鉴定分别为Penicillquei A(1),Penicillquei B(2), Pyrophen (3), Alaromydien A(4), Penicillar E(5), Aculene D(6), Sordaricin (7), BE-31405 (8), Vermistatin (9), Aspergillumarin A(10)和Aspergillumarin B (11).化合物1和2新化合物.抑菌活性测试表明化合物2,3,7和8具有广谱的抗植物病原菌活性.“,”Two new secondary metabolites,penicillqueies A and B (1 and 2),together with penicillquei A (1),penicillquei B (2),pyrophen (3),alaromydien A (4),penicillar E (5),aculene D (6),sordaricin (7),BE-31405 (8),vermistatin (9),aspergillumarin A (10) and aspergillumarin B (11) were isolated from Penicillium herquei JX4.Their structures were elucidated using comprehensive spectroscopic methods.The absolute configuration of penicillquei A was determined by its experimental and calculated electronic circular dichroism (ECD) spectra.Compounds 2,3,7 and 8 showed broad spectrum antifungal activities against nine phytopathogenic fungi.