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已烯雌酚(DES)是一人工合成的雌激素,能对人和许多实验动物诱发肺瘤,但至今尚未证明 DES有明确的致突作用和 DNA 损伤作用,所以 DES 致癌作用精确的分子机制至今尚未明了。近几年来,越来越多的证据表明 DES 的代谢产物是引起肿瘤发生的原因。体外和体内研究均已表明,DES 与肝微粒体组分温育或接触氧化酶/H_2O_2后,产生反应性中间化合物,该中间化合物能与 DNA 和蛋白质共价结合,所以,认为 DES 的致癌性由此引起。SCE 试验是检测许多诱变物的一种非常敏感的方
Diethylstilbestrol (DES) is a synthetic estrogen that induces lung tumors in humans and many laboratory animals. However, DES has not been shown to have a definite mutagenicity and DNA damage effect, so the precise molecular mechanism of DES carcinogenesis So far not yet clear. In recent years, more and more evidence shows that DES metabolites are the cause of tumorigenesis. Both in vitro and in vivo studies have shown that incubation of DES with liver microsomal components or exposure to oxidase / H 2 O 2 results in the production of reactive intermediate compounds that are covalently attached to DNA and proteins and therefore suggest that the carcinogenicity of DES As a result. The SCE test is a very sensitive test for many mutagens