以Bu4NAuCl4为催化剂,H2O2作为氧化剂,在温和的反应条件下实现了叔胺氮的邻位碳原子上sp3-C—H与硝基烷烃的氧化偶联.反应条件温和,室温、空气下即可进行,适用范围广泛,产率高,后处理方便.为新的C—C键的形成提供了一条简洁高效的反应路径,并且合成了一系列可能具有重要药理和生物活性的β-硝基氨化合物. Using Bu4NAuCl4 as catalyst and H2O2 as oxidant, the oxidative coupling of sp3-C-H to nitroalkane on ortho-carbon atom of tertiary amine nitrogen was achieved under mild reaction conditions.The reaction conditions were mild, room temperature, under air For a wide range of applications, high yield, easy post-treatment for the formation of a new C-C bond provides a simple and efficient reaction path, and the synthesis of a series of important pharmacological and bioactive β-nitroamines Compound.