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目的比较氨氯地平联合阿托伐他汀应用对高血压病患者颈动脉粥样硬化斑块的影响及临床意义。方法原发性高血压病患者联用组43例和单用组40例,单用组使用氨氯地平5～10 mg,1次/d;联用组在单用组基础上加用阿托伐他汀10 mg,每晚1次,比较治疗前后两组颈动脉粥样硬化斑块水平、血压、脉压及血脂情况。结果两组的降压幅度比较差异无统计学意义(P>0.05)。与治疗前相比,单用组颈动脉内膜-中层厚度(IMT)、颈动脉平均斑块数及检出率均有显著降低(P<0.05);胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白胆固醇(HDL-C)无显著改变(P>0.05)。联用组颈动脉内膜中层厚度、颈动脉平均斑块数、检出率及TC、TG、LDL、HDL-C均显著降低(P<0.01)。结论原发性高血压病患者氨氯地平与阿托伐他汀联合应用在更好地降低血压的同时,能更为有利地逆转颈动脉斑块。
Objective To compare the effect of amlodipine and atorvastatin on carotid atherosclerotic plaque in patients with essential hypertension and its clinical significance. Methods 43 cases of patients with essential hypertension and 40 cases of single use group, single use of amlodipine 5 ~ 10 mg, 1 / d; combination group on a single use group with Attorney The level of carotid atherosclerotic plaque, blood pressure, pulse pressure and blood lipid in two groups were compared before and after treatment with statin 10 mg once a night. Results There was no significant difference between the two groups (P> 0.05). The carotid intima - media thickness (IMT), carotid mean plaque count and the detection rate were significantly decreased (P <0.05), cholesterol (TC), triglyceride ), Low density lipoprotein (LDL) and high density lipoprotein cholesterol (HDL-C) had no significant change (P> 0.05). Carotid artery intima-media thickness, mean carotid plaque count, detection rate, TC, TG, LDL and HDL-C in combination group were significantly decreased (P <0.01). Conclusion Combination of amlodipine and atorvastatin in patients with essential hypertension can reduce the blood pressure better and at the same time can reverse the carotid artery plaque more favorably.