刺番荔枝 Annona muricata 是一种原产于中美洲的果树。其种子的甲醇抽提物有生物活性。通过溶剂分离并辅以生物检测,采用柱层析,薄层层析等纯化技术得到刺番荔枝素(1,murisolin),这是第三个具有单四氢呋喃脂肪族γ-内酯结构的例子。之前发现来自密毛番荔 Annona densicoma 的番荔枝素(an-nonacin)和来自大哥纳香 Goniothalamus gigan-teus的哥纳香素(goniothalamicin) 也有相同结构特征。刺番荔枝素表现细胞毒素活性(VERO, ED_(50)<0.1μg/ml;KB,ED_(50)<10~(-3)μg/ml,海虾试验LD_(50)=2mg/L)。粉碎的刺番荔枝的种子(860g)在索氏提 Soursop Annona muricata is a fruit tree native to Central America. The methanol extracts of its seeds are biologically active. Separation of solvent and supplemented by biological detection, column chromatography, thin layer chromatography and other purification techniques to obtain saccharomedonin (1, murisolin), this is the third example of mono-tetrahydrofuran aliphatic γ-lactone structure. It was previously found that the annonacin from Annona densicoma and the gonoothalamicin from Goniothalamus gigan-teus also have the same structural features. The spurs showed cytotoxin activity (VERO, ED_(50)<0.1μg/ml; KB, ED_(50)<10~(-3)μg/ml, shrimp shrimp test LD_(50)= 2mg/L) . Seeds of smashed Soursop (860g) in Sothos