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目的通过检测浸润性乳腺癌中白细胞介素18(IL-18)和血管内皮生长因子(VEGF)的表达情况,探讨其表达相关性及与临床病理学参数的关系。方法应用免疫组织化学法检测IL-18和VEGF在42例浸润性乳腺癌组织和12例正常乳腺组织中的表达情况。结果 IL-18和VEGF在42例浸润性乳腺癌中的表达阳性率均显著高于12例正常乳腺组织(P<0.05)。且在42例浸润性乳腺癌组织中,IL-18阳性组中VEGF阳性率(87.1%)显著高于IL-18阴性组中VEGF阳性率(12.9%),差异有统计学意义(P<0.05)。在亚组分析中,IL-18的表达只与有无腋窝淋巴结转移有相关性(P<0.05),而VEGF的表达与有无腋窝淋巴结转移和TNM分期有相关性(P<0.05)。结论在浸润性乳腺癌中,IL-18的表达上调与VEGF的表达上调显著相关,IL-18可能具有促进肿瘤新生血管形成的作用。
Objective To detect the expression of interleukin 18 (IL-18) and vascular endothelial growth factor (VEGF) in invasive breast cancer, and to explore the relationship between the expression of IL-18 and clinicopathological parameters. Methods Immunohistochemical method was used to detect the expression of IL-18 and VEGF in 42 invasive breast cancer tissues and 12 normal breast tissues. Results The positive rates of IL-18 and VEGF in 42 invasive breast carcinomas were significantly higher than those in 12 normal breast tissues (P <0.05). The positive rate of VEGF (87.1%) in IL-18 positive group was significantly higher than that of IL-18 negative group (12.9%) in 42 invasive breast cancer tissues, the difference was statistically significant (P <0.05 ). In the subgroup analysis, the expression of IL-18 was only correlated with the presence or absence of axillary lymph node metastasis (P <0.05), while the VEGF expression was correlated with the axillary lymph node metastasis and TNM stage (P <0.05). Conclusions In invasive breast cancer, the upregulation of IL-18 is significantly associated with the up-regulation of VEGF expression. IL-18 may promote neovascularization of tumor.