论文部分内容阅读
在血脑屏障的通透性正常或有改变的情况下,甘油对脑内水与电解质的作用,仍未充分了解。本文报告用局部冷冻诱发狗之脑水肿,18小时后用10%甘油—氯化钠溶液静滴6或10小时,分别观察脑脊液压力,脑的白质与灰质的含水量,脑脊液与血浆渗透浓度,血浆与脑脊液的电解质含量,含水量等。从本文资料说明,在实验性脑水肿的动物,静注甘油可成功地减少水的含量使之低于正常达10小时之久。脑容积减少是由于正常脑组织脱水而非水肿的脑组织脱水。甘油与其他高渗剂不易通过血脑屏障,因此静脉输入后由于渗透压梯度可使水份由脑向血浆单向运动,达到脱水作用。甘油使灰质含水量减少的程度不如白质。在输入6或10小时后,灰质中甘油浓度高于白质,提示甘油在血浆与灰质之间更迅速达到平衡。在本组中,持续输入甘油10小时之后,看起来
The effect of glycerol on water and electrolytes in the brain is not well understood until the permeability of the blood-brain barrier is normal or altered. This article reports the use of local freezing induced brain edema in dogs, after 18 hours with 10% glycerol - sodium chloride solution intravenous infusion of 6 or 10 hours were observed cerebrospinal fluid pressure, brain white matter and gray matter water content, cerebrospinal fluid and plasma osmolality, Plasma and cerebrospinal fluid electrolyte content, water content and so on. From the data presented here, intravenous glycerol successfully reduced water levels in animals with experimental brain edema to below normal levels for up to 10 hours. Decreased brain volume is due to dehydration of brain tissue in normal brain tissue rather than edema. Glycerol and other hypertonic agents are not easy to pass the blood-brain barrier, so the osmotic pressure gradient can make the water move from brain to plasma unidirectionally after the intravenous infusion to reach the dehydration effect. Glycerol reduces the water content of gray matter to a lesser degree than white matter. After 6 or 10 hours of input, the glycerol concentration in the gray matter is higher than that of the white matter, suggesting that glycerol more rapidly reaches equilibrium between plasma and gray matter. In this group, after 10 hours of continuous input of glycerol, it looks