论文部分内容阅读
目的改进扎利罗登的合成工艺。方法以1-苄基-4-哌啶酮及1-溴-3-三氟甲苯为原料,经还原、消除、加成、成盐等反应合成扎利罗登。结果产品总收率为28.5%,并用质谱、氢谱等鉴定了目标物的结构。HPLC法检测纯度达到99.2%。结论改进后的方法优化了反应条件和投料比,缩短了反应时间,简化了操作步骤,适合工业化生产。
Purpose To improve the synthesis process of Zaliladen. Methods 1-Benzyl-4-piperidone and 1-bromo-3-trifluoromethylbenzene were used as starting materials to synthesize zalolidon through reduction, elimination, addition and salt formation. Results The total product yield was 28.5%, and the structure of the target substance was identified by mass spectrometry, hydrogen spectrum and the like. HPLC purity of 99.2%. Conclusion The improved method optimizes the reaction conditions and feed ratio, shortens the reaction time, simplifies the operation steps, suitable for industrial production.