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目的探讨联合抗氧化微量营养素(combined antioxidant micronutrients,CAM)对肾脏超微结构的保护作用。方法用小剂量多次注射链脲佐菌素法(multiple low dosage of streptozotocin,MLDS)方法制备T1DM(type 1 diabetes mellitus)小鼠模型,分别添加4种和7种抗氧化微量营养素干预,观察肾脏超微结构的变化。结果联合补充抗氧化微量营养素使T1DM小鼠血糖明显降低;微量元素添加组肾小球基底膜厚度明显小于T1DM模型组(P<0.01);系膜区面积明显小于T1DM模型组(P<0.01)。结论 CAM对T1DM模型小鼠肾脏超微结构具有保护作用。
Objective To investigate the protective effect of combined antioxidant micronutrients (CAM) on renal ultrastructure. Methods A type 1 diabetes mellitus (T1DM) mouse model was established by low dose of streptozotocin (MLDS). Four and seven antioxidant micronutrients were added respectively to observe the effects of kidney Changes in ultrastructure. Results Compared with the T1DM model group (P <0.01), the thickness of the glomerular basement membrane in the trace element addition group was significantly lower than that in the T1DM model group (P <0.01) . Conclusions CAM has a protective effect on renal ultrastructure in T1DM mice.