论文部分内容阅读
表面活性物质是一种复杂的由脂类和蛋白质组成的混合物,其成分在哺乳动物体内相当稳定。对支气管肺泡灌洗液进行分析,可发现表面活性物质的组成中90％是脂类,10％是蛋白质。脂类的主要成分是饱和二棕榈酰磷酸酰胆碱,其次是游离胆固醇和负磷脂。蛋白质中,约50％是灌洗液污染物的血清蛋白,其余由4种表面活性剂相关蛋白(SP)组成:SP-A、SP-B、SP-C和SP-D。其中,SP-A和SP-D具有水溶性,易从脂类中分离,不仅能增强细菌和病毒的吞噬作用,还对Ⅱ型肺泡细胞产生调节作用。
Surface-active substances are a complex mixture of lipids and proteins whose constituents are fairly stable in mammals. Analysis of the bronchoalveolar lavage fluid revealed that 90% of the surfactant composition is lipid and 10% is protein. The main component of lipid is saturated dipalmitoylphosphatidylcholine, followed by free cholesterol and negative phospholipid. About 50% of protein is a serum protein of lavage fluid contaminants and the rest consists of four surfactant-related proteins (SPs): SP-A, SP-B, SP-C and SP-D. Among them, SP-A and SP-D are water-soluble and easily separated from lipids, which not only enhance the phagocytosis of bacteria and viruses, but also regulate the type II alveolar cells.