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对53例老年高血压患者的血浆心钠素(ANP)、血栓素B_2(TXB_2)及6-酮-前列腺素F_1α(6-k-PGF_1α)进行测定,并同24名不同年龄健康者进行对比,发现:1.老年高血压患者ANP显著低于健康人而TXB_2、6-K-PGF_1α显著高于健康人。2.老年高血压患者ANP与病程呈负相关;TXB_2与病程呈正相关。3.老年单纯收缩期高血压ANP与收缩压呈负相关;TXB_2与收缩压呈正相关。4.老年经典型高血压ANP与舒张压和平均压呈负相关;TXB_2与舒张压及平均压呈正相关。作者认为:不同年龄不同类型的高血压ANP作用机制不同,在老年高血压患者可能存在ANP绝对量的不足,同时存在明显的TXA_2/PGI_2的代谢异常,TXA_2随病程及年龄增长,合成愈明显升高。PGI_2可能作为防御保护机制在老年高血压病程进展中发挥作用。
The plasma ANP, TXB_2 and 6-keto-prostaglandin F_1α (6-k-PGF_1α) in 53 elderly hypertensive patients were measured and compared with 24 healthy subjects of different ages , Found: 1. ANP in elderly patients with hypertension was significantly lower than healthy people and TXB_2, 6-K-PGF_1α was significantly higher than healthy people. There was a negative correlation between ANP and the course of disease in elderly patients with hypertension; TXB_2 was positively correlated with the course of the disease. The elderly isolated systolic hypertension ANP and systolic blood pressure was negatively correlated; TXB_2 and systolic blood pressure was positively correlated. The senile hypertension with ANP diastolic pressure and mean pressure was negatively correlated; TXB_2 and diastolic pressure and mean pressure were positively correlated. The author believes that: different age groups of different types of hypertension ANP mechanism of action in elderly patients with hypertension may exist the absolute amount of ANP deficiency, while there is a significant TXA2 / PGI2 metabolic abnormalities, TXA2 with the course and age, the more obvious the increased synthesis high. PGI_2 may play a role in the progression of hypertension in elderly patients as a defense and protection mechanism.