论文部分内容阅读
Caveolae是细胞表面直径为50～100nm的胞膜穴样内陷,主要由胆固醇、糖基鞘磷脂、鞘磷脂和一些结构蛋白如Caveolin组成。Caveolin-1是Caveolae的主要组成成分,它与细胞骨架蛋白间接偶联来维持Caveolae的内陷形态。Caveolae和Caveolin-1在参与动脉粥样硬化的各种细胞如内皮细胞、巨噬细胞、平滑肌细胞表面都有表达,它们通过对各种细胞功能和多个信号转导途径的调节参与对动脉粥样硬化的形成和发展。
Caveolae is a caveolae with a cell surface diameter of 50-100 nm. It mainly consists of cholesterol, glycosylphosphatidylcholine, sphingomyelin and some structural proteins such as Caveolin. Caveolin-1, a major component of Caveolae, is indirectly coupled to cytoskeletal proteins to maintain caveolae invaginations. Caveolae and Caveolin-1 are expressed on the surface of various cells involved in atherosclerosis, such as endothelial cells, macrophages, and smooth muscle cells. They are involved in the regulation of atheroma by modulating various cellular functions and multiple signal transduction pathways The formation and development of sclerosis.