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５０年代就认识到，暴露在粗精制润滑油环境中，可能使人诱发皮肤癌，这就促使石油工业开始对润滑油和其它石油产品致癌潜在可能性进行探测调查。所选用的方法是称之为老鼠皮肤涂油生物鉴定法的动物试验。这种鉴定试验则太费时间而且费用太贵。本文讨论对基础油致癌性筛选起影
In the 1950s, it was recognized that exposure to crude refined oils may cause skin cancer, prompting the oil industry to begin probing the potential carcinogenicity of lubricants and other petroleum products. The method of choice is an animal test called the Mouse Skin Oiled Bioassay. This qualification test is too time-consuming and expensive. This article discusses the carcinogenicity of base oils screening