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1990年3-8月使用卡波铂治疗26例晚期恶性肿瘤,包括原发不明的颈部转移性癌,非小细胞肺癌、鼻咽癌和恶性黑色素瘤等。在可评价的20例中,总客观有效率(CR+PR)达47％。对非小细胞肺癌,卡波铂和依托泊甙(etoposide足叶乙甙)的联合化疗优于卡波铂单药治疗。毒副作用主要表现为轻度胃肠道反应(0-Ⅱ度)和骨髓抑制,其他的毒副作用有乏力、脱发等。
From March to August 1990, Carboplatin was used to treat 26 cases of advanced malignant tumors, including primary unclear cervical metastatic carcinoma, non-small cell lung cancer, nasopharyngeal carcinoma, and malignant melanoma. In the 20 evaluable cases, the total objective effective rate (CR+PR) was 47%. For non-small cell lung cancer, combination chemotherapy with carboplatin and etoposide is better than carboplatin monotherapy. The main side effects of poisoning are mild gastrointestinal reactions (0-II degree) and myelosuppression. Other toxic and side effects include fatigue and hair loss.